Blar i forfatter "Shen, Peng"

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    • The long noncoding RNA CCAT2 induces chromosomal instability through BOP1-AURKB signaling 

      Chen, Baoqing; Dragomir, Mihnea Paul; Fabris, Linda; Bayraktar, Recep; Knutsen, Erik; Liu, Xu; Tang, Changyan; Li, Yongfeng; Shimura, Tadanobu; Ivkovic, Tina Catela; Cruz De los Santos, Mireia; Anfossi, Simone; Shimizu, Masayoshi; Shah, Maitri Y.; Ling, Hui; Shen, Peng; Multani, Asha S.; Pardini, Barbara; Burks, Jared K.; Katayama, Hiroyuki; Reineke, Lucas C.; Huo, Longfei; Syed, Muddassir; Song, Shumei; Ferracin, Manuela; Oki, Eiji; Fromm, Bastian; Ivan, Cristina; Bhuvaneshwar, Krithika; Gusev, Yuriy; Mimori, Koshi; Menter, David; Sen, Subrata; Matsuyama, Takatoshi; Uetake, Hiroyuki; Vasilescu, Catalin; Kopetz, Scott; Parker-Thornburg, Jan; Taguchi, Ayumu; Hanash, Samir M.; Girnita, Leonard; Slaby, Ondrej; Goel, Ajay; Varani, Gabriele; Gagea, Mihai; Li, Chunlai; Ajani, Jaffer A.; Calin, George A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-15)
      Background & Aims - Chromosomal instability (CIN) is a carcinogenesis event that promotes metastasis and resistance to therapy by unclear mechanisms. Expression of the colon cancer–associated transcript 2 gene (CCAT2), which encodes a long noncoding RNA (lncRNA), associates with CIN, but little is known about how CCAT2 lncRNA regulates this cancer enabling characteristic.<p> <p>Methods - We ...

    • Metformin blocks MYC protein synthesis in colorectal cancer via mTOR-4EBP-eIF4E and MNK1-eIF4G-eIF4E signaling 

      Shen, Peng; Reineke, Lucas C.; Knutsen, Erik; Chen, Meng; Pichler, Martin; Ling, Hui; Calin, George A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-17)
      The antidiabetic drug metformin has been associated with reduced colorectal cancer (CRC) risk and improved prognosis of CRC patients. However, the detailed mechanisms underlying such beneficial effects remain unknown. In this study, we aimed to evaluate metformin activity in CRC models and unveil the underlying molecular mechanisms. We showed that metformin inhibits CRC cell proliferation by arresting ...